Figure 1: An energy landscape model of ligand binding. To analyze the effects of different conformations on the bound ligand, we used surface mutations to stabilize the canonical active and inactive ...

Biochemistry is characterised by weak, non covalent, bonds between large biopolymers which are continuously made and broken at varying reaction strengths. The interaction forces, typified by van der ...

Type 2 transglutaminase (TG2) is an important cancer stem cell survival protein that exists in open and closed conformations. The major intracellular form is the closed conformation that functions as ...

Modifications in angiotensin II and its antagonistic peptides that should have increased in vivo half-lives but not reduced biological activity were studied by determining the effect of α -methylation ...

Researchers have determined the mechanism underlying antibody hinge conformational changes, which could contribute to the development of more effective cancer treatments. A research team from the ...

Vol. 59, No. 7, Special Issue: Photosynthesis: CO 2 uptake and the pathways of carbon fixation (2008), pp. 1605-1614 (10 pages) Treatment of purified Rubisco with agents that specifically oxidize ...