Cdc7 kinase, in complex with its regulatory subunit Dbf4, orchestrates the initiation of eukaryotic DNA replication by phosphorylating components of the Mcm2–7 helicase complex at replication origins.
Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...
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