The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States' fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...

The group of researchers were the first to take snapshots of the moment naloxone reverses an opioid overdose in the brain.

America remains in the grips of an opioid epidemic. Over the past 25 years or so, opioid overdose deaths have been rising steadily, reaching a record 81,806 in 2022, and not budging much since. Drugs ...

Scientists may be one step closer toward more effective treatments for opioid overdose after a new compound was discovered to improve the success rates of existing treatments. America has been in the ...

July 3 (UPI) --U.S. researchers said Wednesday that they have identified a new drug that could make inroads on the devastation caused by opioids -- by supercharging naloxone, branded as Narcan, the ...

Opioid antagonists are medications people can take to treat opioid use disorder. They help by reducing withdrawal symptoms, addressing cravings, and managing overdoses. Doctors prescribe opioid ...