Autoimmune diseases are among the most puzzling because turncoat constituents of the body wage a constant state of war. Sometimes the underlying cause of an autoimmune condition is so obscure—hidden ...

A team of researchers, affiliated with UNIST have unraveled the molecular mechanisms behind the activation of multiple inflammasomes and their role in inducing inflammatory cell death. This discovery ...

A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting off infections. However, its chronic activation is also implicated in a variety of common ...

Inflammasomes are multiprotein platforms that detect pathogenic or damage‐associated signals within the cytosol and coordinate innate immune responses through caspase-1 activation, the processing of ...

An international team of researchers from LMU and the Helmholtz Centre for Infection Research has visualized the structure of the so-called ASC speck. A central component of the human immune system, ...

Submission of the IND Amendment enables the commencement of a Diabetic Macular Edema (DME)/Diabetic Nephropathy (DN) Phase 2b clinical trial to be undertaken by the DRCR Retina Network, which is ...

Researchers in the lab of Harvard Medical School structural biologist Hao Wu have deciphered the step-by-step assembly of a molecular complex that's crucial for fighting off infections but can also ...

For the first time, researchers have captured the formation of a key driver of inflammatory responses inside intact human cells. Pioneering a new system for observing molecular assemblies, researchers ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, ...

An international team of researchers has visualized the structure of the so-called ASC speck. A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting ...