Nanodiscs have emerged as a transformative platform for the study of membrane proteins, offering a native‐like lipid bilayer environment that preserves protein structure and function outside of the ...

Located at the cellular interface, membrane proteins play critical regulatory roles in the signaling between a cell and its interacting environment, making them popular and ideal drug targets.

Understanding the best ways to get a membrane protein to its destination in a cell is crucial, and the best method to make this happen is still unclear. Cell-free systems allow for interactions ...

Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these ...

Scientists have long known that cellular membranes vary in thickness, but measuring those differences inside actual cells has ...

Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Lysosomes are the recycling centers of human cells. Larger molecules are broken down inside the membrane-enclosed vesicles. Malfunctions can lead to neurodegenerative diseases such as Parkinson's.

BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

A revolution has occurred in the field of pharmaceutical development due to the development of drugs that target membrane proteins. It is estimated that one-third of currently available drugs target G ...

Water deficit during flowering can severely disrupt petal expansion, water uptake, and reproductive success, yet many plants ...

When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies.