The Bills are 2.5-point home favorites in the latest Eagles vs. Bills odds from DraftKings, while the over/under for total points scored is 44.5. Buffalo's over/under for total team points is 24.5, while Philadelphia's is 20.

Look for the Raiders to win the No. 1 overall pick by losing to the Giants, and for the Bucs and Panthers to set the stage for a Week 18 showdown to decide the NFC South.

Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,

We went 9-6-1 last week (including 4-1 on top picks), which brings us to 133-105-2 on the year. That ranks No. 1 at CBS Sports. We benefited from the Chicago Bears' remarkable comeback over the Green Bay Packers,

One of the hottest teams in the NFL right now, led by their No.1 defense, kicks off the Saturday action. C.J. Stroud and the Houston Texans travel to face the Los Angeles Chargers. Both teams are fighting for AFC positioning, making every possession feel like January football.