Promoting pyroptosis-an inflammatory form of programmed cell death-has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain ...

A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis — the process of cell death that is usually caused by infections and results in ...

Multiple strategies have been employed by pathogenic bacteria to sabotage host innate immune signaling to facilitate their infection. Previous studies revealed that the Yersinia effector protein YopJ ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Robust pancreatic tumor suppression by a novel combination treatment with anti-PD-1 immune checkpoint antibody and stroma modifying RNA oligonucleotide STNM01 in mice. This is an ASCO Meeting Abstract ...

An “explosive” form of cell death, called pyroptosis, is part of the normal immune response to the toxins released by bacteria during an infection. But when the infection reaches the lungs, pyroptosis ...

A new study, published in Science, explores what happens in the body when bacteria like Yersinia and Salmonella are at peak activity. That could come in handy. Not only because Yersinia still exists ...

Molecular mechanism by which Yersinia escapes RIPK1-mediated pyroptosis by interfering with host cell glucose homeostasis to activate AMPK. Credit: Xu Daichao According to a study published in Nature ...