Nature

Preclinical characterization of EGT710, an oral non-peptidomimetic reversible covalent SARS-CoV-2 main protease inhibitor

SARS-CoV-2 is the third highly pathogenic coronavirus to emerge in the last 20 years. Although effective vaccines have been developed at unprecedented speed, there remains a need to develop antivirals ...
Nature

1, 4-benzodioxan-substituted Thienyl chalcone derivatives as novel reversible inhibitors of human monoamine oxidase B with anti-neuroinflammatory activity

There are two types of MAO-B inhibitors currently used in clinical practice (Fig. 1A). The first type is the irreversible inhibitors, including R-(-)-deprenyl and rasagiline, which could covalently ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...