Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
Note that both pathways are triggered by glutamate and require calcium, although the calcium comes form different, non-overlapping sources. These opposing pathways act to keep excitation and ...
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