The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P), formed by activation of sphingosine kinase in response to diverse stimuli, is an important lipid mediator that has novel dual ...
Sphingolipids comprise a complex family of naturally occurring molecules that are enriched in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids also serve as a ...
Capsaicin, a novel radiosensitizer, acts via a TRPV6 mediated phenomenon. Background: Hypoxia promotes neovascularization, metastasis, growth and resistance to treatments. The activation of HIF-1α has ...
: (A) Representative images of S1pr3 immunofluorescence staining (upper panel, scale bar = 50 μm), HE staining (middle panel, scale bar = 100 μm), and Masson's trichrome staining (lower panel, scale ...
In a recent study posted to the bioRxiv* preprint server, researchers explored sphingosine kinases (SK) inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry. Study: Sphingosine ...
Sphingolipids are important biological molecules, a class of lipids that have a backbone of sphingoid bases including sphingosine (aliphatic amino alcohol) or another structurally similar compound. In ...
Analytical validation of the Oncomine Immune Response Research Assay (OIRRA) in a CLIA and CAP regulated laboratory for formalin fixed, paraffin embedded (FFPE) solid tumor specimens. Effect of the ...
Sphingosine is a membrane component in all cells and constitutes 25% of the lipid in the myelin sheath. Sphingosine is phosphorylated by ubiquitously expressed sphingosine kinases. S1P regulates cell ...
Measuring circulating blood levels of a specific lipid, sphingosine, allows clinicians to predict whether COVID-19-positive patients will go on to develop symptoms or remain asymptomatic. Researchers ...
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