Notably, when there is no prior knowledge of the inhibition type, the mixed inhibition type model, which involves two inhibition constants, is applicable, since it can describe all types of enzyme ...

Cholinesterase inhibitors prevent the breakdown of a type of neurotransmitter called acetylcholine. Doctors may prescribe this medication for certain neurodegenerative diseases, such as Alzheimer’s ...

α-Glucosidase is a key enzyme in the final step of carbohydrate digestion, cleaving terminal glucose residues from oligosaccharides at the intestinal brush border. Inhibition of this enzyme delays ...

A new method developed by researchers at KAIST and Chungnam National University could drastically streamline drug interaction testing—replacing dozens of traditional experiments with just one. The ...

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from ...

Blocking the NAD hydrolase may save axons from neurodegeneration, if researchers can figure out a safe way to do it ...

Immunotherapy is one of the pillars in the fight against cancer and aims to enable the body's own immune system to fight a tumor. A recent study now shows that removing certain enzymes that regulate ...

The results of a preclinical study by lymphoma researchers at Weill Cornell Medicine suggest that an emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some ...

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system. Anaplastic large cell lymphoma (ALCL) belongs to the subgroup of ...

Researchers at Indiana University have identified a single enzyme in brain neurons that, when removed, sharply reduced the buildup of amyloid plaques in a mouse model of Alzheimer’s disease. The ...

Anticoagulant therapy remains central to the prevention and treatment of thromboembolic disease, including atrial fibrillation, venous thromboembolism, and ...