In the first game, the Detroit Lions host the Green Bay Packers. The Lions are small favorites in this big NFC North game, and the point total currently sits at 48.5 on BetMGM. The next two Thanksgiving Day games have even higher totals, and considering the teams, it’s not a big surprise.

The Cardinals are 3-8 and have lost three straight games and eight of their last nine. They are coming off a 27-24 overtime loss to the Jacksonville Jaguars, a game in which they forced four turnovers and didn't give the ball away themselves,

NFC North opponents clash when the Detroit Lions (7-4) host the Green Bay Packers (7-3-1) on Thursday, November 27, 2025 at Ford Field. Detroit is favored by 2.5 points. The over/under has been set at 49.

Let's update our NFL Power Rankings ahead of Week 13. We also picked out Thanksgiving memories for 31 teams that have played on the holiday (sorry, Jaguars).

Our PackersNews coverage team predicts the outcome of the Green Bay Packers Week 13 game against the Detroit Lions on Thanksgiving.