Background Penetrance of breast cancer (BC) among women who carry pathogenic variants (PVs) in BRCA1 is incomplete, and the ...

Frontier Medicines Corporation, a clinical-stage precision medicines company unlocking the proteome to develop small molecule oncology and immunology drugs against previously undruggable ...

Genetic mutations found in the body’s immune response are “significantly associated” with earlier breast cancer onset among ...

Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast ...

Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among ...

Researchers have engineered a new class of adenine base editors that reduce unwanted bystander mutations by two to three ...

Being invited to present research at an international academic conference is an honor for any seasoned professional. But for 16-year-old Lucas Wang, it was an opportunity to kick start what he hopes ...

An HR advisor with a background in recruitment and HRIS functions, with a passion for video games and writing. Oliver grew up playing Call of Duty with his siblings and has garnered 1000s of hours ...

Missense mutations have been extensively studied in tumor-suppressing antigens (TP53) to understand oncogenesis within malignant epithelial cells. Using Whole Exome Sequencing (WXS), missense ...

An international team of scientists headed by researchers at the University of Edinburgh, has created a complete map showing how hundreds of possible mutations in a key cancer gene, CTNNB1, influence ...

In mantle cell lymphoma (MCL), an aggressive form of B-cell non-Hodgkin lymphoma, TP53 mutations are known to affect patients’ prognosis—but questions remain. What does the heterogeneity of TP53 ...

Introduction Marfan syndrome (MFS) is an autosomal dominant condition characterised by a wide array of pleiotropic manifestations that affect the cardiovascular, skeletal, ocular and pulmonary systems ...