When it premiered in 2023, HBO’s The Last of Us was hailed by many as the best video game adaptation ever. A huge part of that acclaim was attributed to how closely series’ creators Craig Mazin and Neill Druckmann (who co-created the game) stuck to the script when translating the 2013 title to television.

Spores play a major role in The Last of Us Part II, mainly for how Dina finds out Ellie is immune; in the show Ellie gets bitten defending Dina, while in the game Ellie's gas mask gets broken in the spore-filled subway tunnel.

In The Last of Us Part 2, we meet Isaac when we're playing as Abby, at the end of Seattle Day One - around 9 hours into the game, after we've played through Ellie's perspective. A