Cell- and animal-based models of bone formation reveal novel mechanisms involved in the cartilage-to-bone phenotype ...

Animal studies have shown that some cartilage cells can transition to a bone-like phenotype, challenging the belief that bone cells arise solely from ...

Researchers at Peking University has developed a "two-step" signaling switch—transitioning from Hippo-YAP/Notch to TGFβ1 pathways—to capture and ...

How do blood vessels stay strong, flexible, and responsive to the body's changing need for oxygen and nutrients? The answer lies not only in biology—but also in physics. Researchers at Åbo Akademi ...

Immunome is advancing varegacestat for desmoid tumors, targeting NDA submission in Q2 2026 after positive phase 3 RINGSIDE ...

Activity levels of four genes linked to the Notch signaling pathway — which helps regulate cell growth, tissue repair, and immune responses in the body — may serve as blood-based biomarkers that could ...

Hematopoietic stem cells (HSCs) emerge in vertebrate embryos under the coordinated regulation of multiple signaling pathways. Despite advances in developmental biology, robust protocols for generating ...

A research team from Shenyang Agricultural University, led by Dr. Bin Li, has highlighted the potential of malvidin-3-O-galactoside (M3G), a blueberry-derived anthocyanin, to improve colonic mucosal ...

Department of Ophthalmology, National Taiwan University Hospital, Hsinchu Branch, Hsinchu 302, Taiwan Department of Ophthalmology, National Taiwan University Hospital, Taipei 100, Taiwan Graduate ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...