Musk tapped Yaccarino to replace him as CEO in 2023, shortly after purchasing the platform, then called Twitter, for $44 billion in October 2022. He said Yaccarino would focus primarily on Twitter's business while he focused on product design and new technology.

Yaccarino announced her departure on the social media platform but didn't say why a day after the platform's Grok chatbot posted a series of antisemitic statements.