Europe PMC

Real-World Clinical Evidence With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy ― A Contemporary Review ―

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Europe PMC

Chemicals seeping from the sea floor sustain an extreme-depth ecosystem.

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Europe PMC

Safe model based optimization balancing exploration and reliability for protein sequence design.

Discovering proteins with desired functionalities using protein engineering is time-consuming. Offline Model-Based Optimization (MBO) accelerates protein sequence design by exploring the vast protein ...
Europe PMC

Retrospective Analysis of Carpal Tunnel Syndrome: Clinical Profile, Demographics, and Risk Factors at Sohar Hospital Over a Two-Year Period

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A structural switch reveals how to disarm USP30 and unlock mitophagy.

Affiliations 1. Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Authors Fitzgerald JC 1 Authors Fitzgerald JC 1 (1 ...
Europe PMC

The Pathways Segmentation Approach: A Novel Application for Identifying Intersecting Vulnerabilities in Public Health

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Europe PMC

Optimization of the KK5 Scaffold and Biological Evaluation of KK5 Derivatives to Identify Potent Strigolactone Biosynthesis Inhibitors.

Abstract Strigolactones (SLs) are germination stimulants for root-parasitic weeds, such as Striga spp., Orobanche spp., and Phelipanche spp., which cause significant damage to agricultural crops.
Europe PMC

Identification of an episignature for CHD3-related Snijders Blok-Campeau syndrome reveals heterogeneity in the CHARGE syndrome episignature: towards a better characterization ...

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Europe PMC

Efficacy and Safety of Switching from Baricitinib to Ritlecitinib in Severe Alopecia Areata.

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Europe PMC

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

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Europe PMC

Structure and activity of the Lugdulysin M30 zinc metallopeptidase, a potential virulence factor from Staphylococcus lugdunensis

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A myelinic channel system for organelle transport to the glial-axonal junction

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