Spores play a major role in The Last of Us Part II, mainly for how Dina finds out Ellie is immune; in the show Ellie gets bitten defending Dina, while in the game Ellie's gas mask gets broken in the spore-filled subway tunnel.

When it premiered in 2023, HBO’s The Last of Us was hailed by many as the best video game adaptation ever. A huge part of that acclaim was attributed to how closely series’ creators Craig Mazin and Neill Druckmann (who co-created the game) stuck to the script when translating the 2013 title to television.

In The Last of Us Part 2, we meet Isaac when we're playing as Abby, at the end of Seattle Day One - around 9 hours into the game, after we've played through Ellie's perspective. A