APOE encodes a secreted apolipoprotein involved in lipid metabolism. It is best known for its three major alleles—APOE2, APOE3, and APOE4 —with APOE4 increasing the risk for …

May 10, 2024 · For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists argue …

May 10, 2024 · This is a very appealing study on neuropathological changes and in vivo biomarkers in APOE4 homozygotes. A better knowledge on the history of biomarkers in …

Aug 16, 2024 · They discovered stark differences by ApoE genotype, whereby ApoE4 microglia mounted largely pro-inflammatory responses to amyloid, with many of their dysregulated …

APOE4 blunted immune cell chemotaxis and autophagy, while boosting vesicle fusion, synaptic signaling, and vascular activity. It exerted its greatest effect on microglia, OPCs, and vascular …

Dec 13, 2022 · It is well-established that the common APOE variants, C130R (APOE4) and R176C (APOE2), modify Alzheimer’s disease risk, boosting it in the former and reducing it in …

Jan 29, 2025 · The APOE4 Targeted Replacement model is one line in a set of three APOE knock-in lines created by Nobuyo Maeda, Patrick Sullivan, and colleagues. APOE2 and …

Oct 4, 2023 · The epsilon-4 allele of Apolipoprotein E and the R47H variant of Trem2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in …

Jan 8, 2025 · Findings In November 2019, investigators at Weill Medical College of Cornell University began a Phase 1 trial evaluating LX1001 in 15 volunteers who carry two APOE4 …

Oct 19, 2025 · It enrolled 325 ApoE4 homozygotes with clinically diagnosed early to mild AD. Participants received 265 mg of ALZ-801 or placebo twice daily for 18 months. The primary …